Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Heather Young
Tanzania
Research Article
Low-dose Ketamine for Children and Adolescents with Acute Sickle Cell
Disease Related Pain: A Single Center Experience
Author(s): Caitlin M Neri, Sophie R Pestieau, Heather Young, Angelo Elmi, Julia C Finkel and Deepika S DarbariCaitlin M Neri, Sophie R Pestieau, Heather Young, Angelo Elmi, Julia C Finkel and Deepika S Darbari
Background: Opioids are the mainstay of therapy for painful vasoocclusive episodes (VOEs) in sickle cell disease (SCD). Based on limited studies, low-dose ketamine could be a useful adjuvant analgesic for refractory SCD pain, but its safety and efficacy has not been evaluated in pediatric SCD.
Procedure: Using retrospective chart review we recorded and compared characteristics of hospitalizations of 33 children with SCD hospitalized with VOE who were treated with low-dose ketamine and opioid PCA vs. a paired hospitalization where the same patients received opioid PCA without ketamine. We seek to 1) describe a single center experience using adjuvant low-dose ketamine with opioid PCA for sickle cell related pain, 2) retrospectively explore the safety and efficacy of adjuvant low-dose ketamine for pain management, and 3) determine ketamine’.. View More»
DOI:
10.4172/2155-6148.1000394