Journal of Cell Signaling
Open Access
ISSN: 2576-1471
ISSN: 2576-1471
Hélène Lallet-Daher
France
Research Article
Involvement of Ion Channels in Endothelin-1-induced Signalling in Human Prostate Cancer Cells
Author(s): Eric Vancauwenberghe, Hélène Lallet-Daher, Sandra Derouiche, Pascal Mariot, Pierre Gosset, Philippe Delcourt, Brigitte Mauroy, Jean-Louis Bonnal, Laurent Allart, Natalia Prevarskaya and Morad RoudbarakiEric Vancauwenberghe, Hélène Lallet-Daher, Sandra Derouiche, Pascal Mariot, Pierre Gosset, Philippe Delcourt, Brigitte Mauroy, Jean-Louis Bonnal, Laurent Allart, Natalia Prevarskaya and Morad Roudbaraki
Objective: Endothelin-1 (ET-1), a potent vasoconstrictor secreted primarily by endothelial and various epithelial cancer cells has been implicated in prostate cancer progression and the ET axis has been suggested to represent a novel and exciting target in the treatment of prostate cancer (PCa). ET-1, acting primarily through the endothelin receptors (ETRs) is integrally involved in multiple facets of PCa progression, including cell growth, inhibition of apoptosis, angiogenesis and development of bone metastases. ET-1 and ETRs are expressed in PCa tissues and their expression is modulated during the evolution of these cancers. The purpose of the present work was to study the effects of ET-1 on proliferation of human PCa cells PC-3 and the mechanisms by which the activation of ETRs may promote the PCa cells growth. Methods: Prostate cancer cell lines and primary cultured epithelial cel.. View More»
DOI:
10.4172/2576-1471.1000126