Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Hazilawati Hamzah
43400 Serdang, Selangor
Malaysia
Research Article
Blood Profiles and Histopathological Changes of Liver and Kidney Tissues from Male Sprague Dawley Rats Treated with Ethanol Extracts of Clinacanthus nutans Leaf.
Author(s): Sajjarattul Nurul Nadia Asyura, Hazilawati Hamzah, Rosly Mohamad Shaari, Shanmugavelu Sithambaram and Noordin Mohamed MustaphaSajjarattul Nurul Nadia Asyura, Hazilawati Hamzah, Rosly Mohamad Shaari, Shanmugavelu Sithambaram and Noordin Mohamed Mustapha
Background: Clinacanthus nutans (C. nutans) or commonly known as ‘Sabah snake grass’ or ‘Belalai Gajah’ is a widely known herb used to treat Herpes simplex virus (HPV), skin rashes and snake bite.
Objective: This study aim is to evaluate the toxicity of ethanol extract of C. nutans leaf extract on 90-day sub chronic toxicity study in male Sprague Dawley rats.
Method: A total of 40, 6-week male Sprague Dawley rats were divided into 5 groups (n=8) namely control, vehicle (10% DMSO), and 3 treatment groups which received a daily oral dose of C. nutans leaf extract at 75 (low dose), 125 (medium dose), and 250 (high dose) mg/kg for 90 days via oral gavage. Blood sample were collected at the end of the experiment for evaluation of haematology and serum biochemis.. View More»
DOI:
10.4172/2161-0495.1000329