Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Harriet Johnston
New Zealand
Research Article
The Utility of Single Nucleotide DNA Variations as Predictors of Postoperative Pain
Author(s): Gregory M. Jacobson, Corinne J. Law, Harriet Johnston, Mark Chaddock, Michal Kluger, Raymond T.M. Cursons and Jamie W. SleighGregory M. Jacobson, Corinne J. Law, Harriet Johnston, Mark Chaddock, Michal Kluger, Raymond T.M. Cursons and Jamie W. Sleigh
Objectives: Genetic variation is an important contributor to postsurgical pain and thereby analgesia requirements. A description of the potential predictive power of genetic variants in pain should instruct improvements in pain management postoperatively. We set out to examine whether a set of genetic variants in pain related genes would show any association with actual pain outcomes in a typical surgical population. Methods: A candidate gene study was carried out in 135 surgical patients with 12 DNA variants (single nucleotide polymorphisms or ‘SNPs’) in known or putative pain pathway genes to detect associations with postoperative pain - measured by a verbal rating score (VRS) and patient-controlled analgesia (PCA) usage rate. Standard PCR based molecular biology approaches were used.
Results: At 20-24h after sur.. View More»
DOI:
10.4172/2155-6148.1000401