Journal of Antivirals & Antiretrovirals
Open Access
ISSN: 1948-5964
ISSN: 1948-5964
Hao Wu
Director of Center for Infectious Diseases, Beijing You’an Hospital,
Beijng, China
Tanzania
Research Article
Prevalence of Transmitted HIV-1 Drug Resistance (TDR) Associated Mutations and Predicted Drug Sensitivity in Newly Diagnosed HIV-1 Patient Cohort in a Western New York, 2005-2011
Author(s): Lili Dai, Supriya D Mahajan, Donald L Sykes, Alyssa Shon, Stanley A Schwartz, Ning Li, Hao Wu and Chiu-Bin HsiaoLili Dai, Supriya D Mahajan, Donald L Sykes, Alyssa Shon, Stanley A Schwartz, Ning Li, Hao Wu and Chiu-Bin Hsiao
HIV-1 drug resistance associated mutations can be transmitted to persons who are antiretroviral-naive, called Transmitted Drug Resistance (TDR). TDR has the potential to compromise first-line anti-retroviral therapy (ART) in HIV patients and limit the antiretroviral regimens options, which has become an important public health problem. TDR surveillance is an important strategy to monitor the emergence of genetic. TDR has been reported in the United States for many years. Current antiretroviral treatment guidelines recommend drug resistance testing after diagnosis. We did a retrospective analysis of the genotype database of ART-naïve patients from our immunodeficiency clinics at the Erie County Medical Center (ECMC) in Buffalo, New York, United States from 2005 to 2011. The prevalence of TDR in the ECMC-US cohort is still high 13.3%. The drug susceptibility is significantly reduce.. View More»
DOI:
10.4172/jaa.1000090