Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Glinavou A
Greece
Research Article
The Role of Cellular Proliferation and Apoptosis in Acute Lung Injury: An Experimental Study
Author(s): Katsoulis IΕ, Athanassoulias V, Theocharis S, Glinavou A and Kouraklis GKatsoulis IΕ, Athanassoulias V, Theocharis S, Glinavou A and Kouraklis G
Introduction: Acute Lung Injury (ALI) is a widespread damage to cells and structures of the alveolar capillary membrane that occurs within hours to days of a predisposing insult. A comprehensive understanding of the mechanisms of apoptosis in the initial injury and repair of lung epithelial and endothelial cells and other key cells involved in ALI is lacking. Further information is required regarding cytokine-signaling pathways, patterns of gene and protein expression. The present study attempts to correlate various parameters of lung damage and expression of certain proteins that regulate the cell cycle in an experimental model of ALI.
Material and methods: ΑLI was induced in five groups of mice via inhalation of paraquat. The animals of each group were sacrificed on days 1,2,3,4 and 6, respectively and their lungs were examined for t.. View More»
DOI:
10.4172/2155-6148.1000424