Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Ghada Attia Eshak
Faculty of Medicine,
Egypt
Research Article
Polycyclic Aromatic Hydrocarbons: Role of Apoptosis in Dermatotoxic and
Carcinogenic Effect in Asphalt Road Paving Workers
Author(s): Ghada Attia Eshak, Morid malak Hanna and Manal Ismael AhmedGhada Attia Eshak, Morid malak Hanna and Manal Ismael Ahmed
Asphalt contains a complex mixture of polycyclic aromatic hydrocarbons (PAHs). This work aimed firstly to assess the dermatotoxic and carcinogenic risk associated with chronic PAHs exposure, and secondly to investigate the causal relationship between PAHs exposure and cancer through studying the effect of PAHs on apoptosis. This effect was studied by examining the expression pattern of P53, Bax and Bcl-2 apoptotic proteins in skin specimens from road paving workers. The study was conducted on one hundred and fifty two male subjects classified into 122 asphalt fumes exposed workers (tested group) and 30 non exposed workers (control group); careful skin examination and skin biopsies were obtained from all participants after written consent. Biopsies were examined histopathologically and immunohistochemically. SPSS version 15.0 was used for statistical analysis. Results showed that 71 (5.. View More»
DOI:
10.4172/2161-0495.1000137