Cell & Developmental Biology
Open Access

George Perry

Biography

George Perry, Ph.D., is Professor and holds the Semmes Foundation Distinguished University Chair in Neurobiology at the University of Texas at San Antonio. He obtained his Ph.D. in Marine Biology from Scripps Institution of Oceanography in 1979 and received a postdoctoral fellowship in the Department of Cell Biology at Baylor College of Medicine where he laid the foundation for his observations of abnormalities in cell structures. Dr. Perry is distinguished as one of the top Alzheimer’s disease researchers with over 1,000 publications, one of the top 100 most-cited scientists in neuroscience and behaviour.

Research Interest

His studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer disease. We have shown that oxidative damage is the initial cytopathology in Alzheimer disease. They are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. Their current studies focus on (i) the mechanism for RNA-based redox metal binding; (ii) the consequences of RNA oxidation on protein synthesis rate and fidelity; (iii) the role of redox active metals in mediating prooxidant and antioxidant properties; (iv) the signal transduction pathways altered in Alzheimer disease that allow neurons to evade apoptosis; and (v) mechanism of phosphorylation control of oxidative damage to neurofilament proteins.

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