Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Friday E. Uboh
Faculty of Basic Medical Sciences,
P.M.B.1115, Calabar
Nigeria
Research Article
Comparative Effect of Withdrawal from Exposure on Gasoline and Diesel Induced Nephrotoxicity in Male Albino Wistar Rats
Author(s): Friday E. Uboh, Saviour U. Ufot and Eyong U. EyongFriday E. Uboh, Saviour U. Ufot and Eyong U. Eyong
Exposure to gasoline and diesel has been reported to induce nephrotoxicity in rats. This study was designed to assess the effect of withdrawal from exposure on the nephrotoxic effects associated with oral exposure to gasoline and diesel in male rats. Four groups of the experimental test rats were respectively exposed orally to diesel and gasoline solvents (4.0 mg/kg/day, 6 days/week) for 60 days, after which two respective groups were sacrificed for nephrotoxicity assay while the remaining two groups were withdrawn from exposure for the next 60 days before sacrificing them for biochemical assay. The results showed that oral exposure to diesel and gasoline induced a significant (p<0.05) increase in serum creatinine, urea, blood urea nitrogen (BUN) and kidney tissue malondialdehyde (MDA), as well as decrease in kidney tissue reduced glutathione (GSH) concentrations in rats. However, .. View More»
DOI:
10.4172/2161-0495.1000170