Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
ISSN: 2329-8790
Review Article
Insufficient Efficiency of Prasugrel in Diabetic Patients with Acute STEMI Undergoing pPCI of Culprit Coronary Lesion – Review of Current Knowledge
Author(s): Samos M, Fedor M, Kovar F, Duraj L, Skornova I, Fedorova J, Galajda P, Stasko J, Bolek T, Kubisz P and Mokan MSamos M, Fedor M, Kovar F, Duraj L, Skornova I, Fedorova J, Galajda P, Stasko J, Bolek T, Kubisz P and Mokan M
The activation and subsequent platelet aggregation plays a key role in the formation of arterial thrombosis and therefore is the key therapeutic target in the treatment of acute coronary syndromes. Dual antiplatelet therapy containing aspirin and P2Y12 ADP receptor antagonist forms currently the basis in acute ST – elevation myocardial infarction (STEMI) pharmacological treatment. Nevertheless, there is a wide variability in pharmacodynamic response to administration of clopidogrel, the most frequently used P2Y12 ADP receptor antagonist. High platelet reactivity after clopidogrel administration is associated with increased risk of in - stent thrombosis and points to the suitability of laboratory monitoring of antiplatelet therapy effectivity in clinical practice. Laboratory monitoring of antiplatelet therapy by ex vivo platelet function tests may help to identify individuals wit.. View More»
DOI:
10.4172/2329-8790.1000120