Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Ezzeldin Ibrahim
Shebeen-Elkoom
Egypt
Research Article
The Effectiveness of Standard Single Dose Omeprazole vs. High Dose Continuous Infusion in High-risk Critically Ill Patients
Author(s): Ezzeldin Ibrahim and Hala KoptanEzzeldin Ibrahim and Hala Koptan
Objectives: The present study was carried out to investigate the beneficial effects of high dose omeprazole versus standard low dose as a prophylaxis against upper GIT bleeding in high risk critically ill patients.
Methods: A hundred and ten high risk critically ill patients were divided into two groups, fifty-five patients each. Group A received intravenous (IV) omeprazole 40 mg bolus dose once daily followed by normal saline infusion. Group B received IV bolus of 80 mg omeprazole followed by 8 mg/h infusion. The treatment was for the whole period of ICU stay. Early morning gastric pH, residual gastric volume, signs of significant upper GIT bleeding, ICU stay Hb, number of ICU days without ventilator, ICU stay hemoglobin (Hb), number of red cell units transfused in ICU, ICU stay, and numbers of ICU survivors were recorded.
Resul.. View More»
DOI:
10.4172/2155-6148.1000819