Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Doaa Safwat Abdel-Magiud
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Branch of New Valley,
Egypt
Research Article
Radical Scavenging Activities of Albumin-Copper Complex against Bromobenzene Induced Hepatotoxicity
Author(s): Doaa Safwat Abdel-Magiud, Ahmed Y. Nassar, Ahmed R. Shatat and Ayman S. MohamedDoaa Safwat Abdel-Magiud, Ahmed Y. Nassar, Ahmed R. Shatat and Ayman S. Mohamed
This study was performed to examine that copper-albumin complex can restore oxidative damage and cytotoxicity in induced by Bromobenzene (BB) in liver. Rats were divided into three groups. Group I served as control received corn oil only. Group II exposed to BB at a dose of 300 mg/Kg by weight, twice/week, orally, dissolved in corn oil for one month. Group III received BB as previous dose plus copper albumin- Serum total protein and albumin showed significant reduction while the activities of ALT and AST enzymes significantly increased in BB-treated group when compared to control. The antioxidant enzymes activities were found to be decreased in BB treated rats in contrast nitric oxide and lipid peroxidation levels were increased in comparison with normal control. Histopathology revealed that BB had a hepatotoxic effects represented by hepatitis and fatty degeneration. Nile blue positi.. View More»
DOI:
10.4172/2161-0495.1000405