Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Daniel A Hansen
Mayo Clinic Arizona,
5777 E Mayo Blvd., Phoenix AZ
Tanzania
Research Article
Preoperative Midodrine Use Does Not Predict Intraoperative Hypotension
During Orthotopic Liver Transplantation
Author(s): Daniel A Hansen, Karl A Poterack, M'hamed Temkit, Mary B Laney CRNA and Terrence L TrentmanDaniel A Hansen, Karl A Poterack, M'hamed Temkit, Mary B Laney CRNA and Terrence L Trentman
Background: Complications of liver transplantation undermine long term benefits for patients with end-stage liver disease. Some patients awaiting liver transplantation are treated with midodrine, an oral α1 agonist. We hypothesized that preoperative use of midodrine would predict increased intraoperative hypotension with associated vasopressor and blood product administration and deleterious effects on graft survival. Methods: We performed a retrospective, matched case control study examining patients receiving midodrine versus those not before undergoing liver transplantation. Sixty-four patients were examined and analyzed. Primary outcomes were total intraoperative vasopressor use and minutes of intraoperative hypotension. Results: For the primary outcomes, no statistically significant difference was found between the groups. No significant differences were seen in one year pa.. View More»
DOI:
10.4172/2155-6148.1000686