Journal of Hematology & Thromboembolic Diseases

Journal of Hematology & Thromboembolic Diseases
Open Access

ISSN: ISSN: 2329-8790


Chie Nishioka

  • Review Article
    What is the Role of Soluble Cytokine Receptors in Adult T-cell Leukemia/ Lymphoma?
    Author(s): Ratiorn Pornkuna, Chie Nishioka and Shigeki TakemotoRatiorn Pornkuna, Chie Nishioka and Shigeki Takemoto

    Soluble cytokine receptors are products of tumor cells infected with viruses such as human T-cell leukemia virus type 1 (HTLV-1). Adult T-cell leukemia/lymphoma (ATLL) is a highly aggressive leukemia/lymphoma caused by HTLV-1. High levels of soluble cytokine receptors are detected in the serum of patients with ATLL. Matrix metalloproteinase (MMP)-9 cleaves the interleukin (IL)-2 receptor α chain (IL-2Rα, CD25), which produces soluble IL-2Rα (sIL-2R) and down-regulates the proliferative capability of T cells that encounter cancer cells. Soluble CD30 (sCD30) impairs the interaction of CD30 ligand+ cells with CD30+ cells, whereas CD30 expression integrates survival signals to NK cells. Accordingly, high level of sIL-2R and sCD30 suggest that not only does impaired tumor surveillance lead to the survival of ATLL cells, but also dysfunction of immune surveillance can cause s.. Read More»
    DOI: 10.4172/2329-8790.1000154

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