Anesthesia & Clinical Research
Open Access

Charlotte Sandersen

Publications

• Research Article
  Effect of High Pressure-Volume and Low Pressure-Volume Mechanical Ventilation on Plasma Concentrations of Inflammatory Markers in Horses during General Anaesthesia
  Author(s): Alessia Cenani, Simona Cerri, Alexandra Gougnard, Johan Detilleux, Thierry Frank, Didier Serteyn and Charlotte SandersenAlessia Cenani, Simona Cerri, Alexandra Gougnard, Johan Detilleux, Thierry Frank, Didier Serteyn and Charlotte Sandersen
  
  Systemic changes of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), neutrophil elastase (ELT) and myeloperoxidase (MPO) during mechanical ventilation (MV) in horses anaesthetized for surgery are evaluated. Thirty-four client-owned ASA I-II horses randomly received mechanical ventilation (MV) with either a peak inspiratory pressure (PIP) of 30 cm H2O and tidal volume (VT)>10 mL kg-1 (high pressure-volume MV) or PIP of 15 cm H2O and VT ≤ 10 mL kg-1 (low pressure-volume MV) in dorsal or lateral recumbency. Horses were premedicated with acepromazine (0.1 mg kg-1 IM) and xylazine (0.6 mg kg-1 IV), induced with midazolam (0.06 mg kg-1 IV) and ketamine (2.2 mg kg-1 IV) and maintained with isoflurane in oxygen 70% plus ketamine-midazolam infusion (1 and 0.02 mg kg-1 h-1, respectively). Anti-inflammatory drug and antibiotics were administered before surgery. Plasmatic pr.. View More»
  DOI: 10.4172/2155-6148.1000478

  Abstract PDF

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