Pancreatic Disorders & Therapy
Open Access
ISSN: 2165-7092
+44 1478 350008
ISSN: 2165-7092
+44 1478 350008
Buyukasik O
Turkey
Research Article
The Effect of Erythropoietin on Intestinal Damage Developed Secondary to Experimental Acute Pancreatitis
Author(s): Kahramansoy N, Bozgeyik M, Erkol H, Bozcaarmutlu A, Kukner A and Buyukasik OKahramansoy N, Bozgeyik M, Erkol H, Bozcaarmutlu A, Kukner A and Buyukasik O
Background: In acute pancreatitis, development of intestinal damage is of clinically importance. Such that, preventing the intestinal damage may restrain severity of the pancreatitis. Erythropoietin which has pleiotropic effects is shown to decrease inflammation, the damage of ischemia-reperfusion, and apoptosis in intestine. Here, it is aimed to obtain the effects of erythropoietin on the intestinal damage caused by the acute pancreatitis.
Methods: Twenty one Wistar Albino rats were separated into three (Sham-Control-EPO) groups. Experimental acute pancreatitis was formed by infusion of the 4.5% Na taurocholate into the pancreatic duct. A 1000 U/kg/day dose of erythropoietin was applied in the EPO group, intraperitoneally for three days. The experiment was terminated on the fourth day. Leukocyte in blood, CRP and amylase in serum were studi.. View More»
DOI:
10.4172/2165-7092.1000106