Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Buwei Yu
Ruijin Hospital, Shanghai Jiaotong University Medical School,
197 Ruijin Er Road, Shanghai 200025
China
Research Article
Sugammadex 4.0 mg kg-1 Reversal of Deep Rocuronium-Induced
Neuromuscular Blockade: A Multicenter Study in Chinese and Caucasian
Patients
Author(s): Buwei Yu, Xiangrui Wang, Hans S Helbo-Hansen, Wen-Qi Huang, Bjarte Askeland, Shitong Li, Zhengnian Ding, Esther Abels, Henk Rietbergen, Tiffany Woo and Philippe PendevilleBuwei Yu, Xiangrui Wang, Hans S Helbo-Hansen, Wen-Qi Huang, Bjarte Askeland, Shitong Li, Zhengnian Ding, Esther Abels, Henk Rietbergen, Tiffany Woo and Philippe Pendeville
Objective: Maintenance of deep Neuro Muscular Blockade (NMB) until the end of surgery may be beneficial in some surgical procedures. The selective relaxant binding agent sugammadex rapidly reverses deep levels of rocuronium-induced NMB. The purpose of this study was to evaluate the efficacy and safety of sugammadex 4.0 mg kg–1 for reversal of deep rocuronium-induced NMB in Chinese and Caucasian patients.
Methods: This was an open-label, multicenter, prospective Phase III efficacy study in adult American Society of Anesthesiologists Class 1-3 patients scheduled for surgery under general anesthesia and requiring deep NMB. All patients received intravenous propofol and opioids for induction and maintenance of anesthesia, and a single intubation dose of rocuronium 0.6 mg/kg, with maintenance doses of 0.1-0.2 mg/kg as required. Sugammadex 4.0.. View More»
DOI:
10.4172/2155-6148.1000408