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Brad A Bryan
Professor at Department of Cardiology
The research in the Bryan lab is focused on the subcellular mechanics and cellular signaling involved in the formation of the cardiovascular system. We are particularly interested in how these pathways are deregulated in aberrant vascular states such as hemangiomas, vascular malformations, and cancer. Insights gained from this work can lead to a better understanding of the cause and treatment of vascular disease and cancer. To achieve these goals, we are developing novel experimental techniques to (1) elucidate the mechanisms by which cell shape and mechanical stress affect gene expression, (2) identify the genetic and epigenetic components controlling hemangioma and vascular malformation progression, and (3) develop advanced therapeutics against a variety of vascular tumors including hemangioendotheliomas and angiosarcomas.