Angiology: Open Access
Open Access

Brad A Bryan

Biography

Brad A Bryan is currently working as Professor at Department of Cardiology, research interest includes  rho kinase proteins—pleiotropic modulators of cell survival and apoptosis, coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiation.
 

Research Interest

The research in the Bryan lab is focused on the subcellular mechanics and cellular signaling involved in the formation of the cardiovascular system. We are particularly interested in how these pathways are deregulated in aberrant vascular states such as hemangiomas, vascular malformations, and cancer. Insights gained from this work can lead to a better understanding of the cause and treatment of vascular disease and cancer. To achieve these goals, we are developing novel experimental techniques to (1) elucidate the mechanisms by which cell shape and mechanical stress affect gene expression, (2) identify the genetic and epigenetic components controlling hemangioma and vascular malformation progression, and (3) develop advanced therapeutics against a variety of vascular tumors including hemangioendotheliomas and angiosarcomas.

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