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Journal of Cell Science & Therapy

Journal of Cell Science & Therapy
Open Access

ISSN: 2157-7013

+44 1300 500008

Bilgimol C Joseph

Publications
  • Editorial
    Induced Pluripotent Stem Cells for the Treatment of Hemophilia A
    Author(s): Bilgimol C Joseph and Manjunath S RaoBilgimol C Joseph and Manjunath S Rao

    Factor VIII, one of the most complex proteins known, plays a major role in blood coagulation pathway. Defects in factor VIII protein result in hemophilia A, a severe bleeding disorder. Plasma derived factor VIII or recombinant factor VIII has been used extensively for treating hemophilia A patients. Number of attempts at gene therapy for hemophilia A has failed for various unknown/not much studied reasons including immune rejection. Here, the progress that has been made in establishing iPSC-based disease models and the potentials of iPSC technology for personalized medicine and cell therapy for hemophilia A are reviewed. The challenges of iPSC technology are also briefly discussed... View More»
    DOI: 10.4172/2157-7013.1000e119

    Abstract PDF

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