Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Banambar Ray
India
Research Article
Effect of Nitric Oxide Inhalation in Acute Pain Crisis of Sickle Cell Disease: A Preliminary Report
Author(s): Dipika Mohanty, Banambar Ray and Shakti Sankar PattanayakDipika Mohanty, Banambar Ray and Shakti Sankar Pattanayak
Background and objectives: The Vaso-occlusive Crisis (VOC) is a very common manifestation of Sickle Cell Disease patients in India which is characterised by severe body, chest and joint pain. The patho-physiology of VOC is due to abnormal nitric oxide dependent regulation of vascular tone, adhesion of sickle cells (deoxygenated) to endothelium, platelet activation and inflammation. Therefore, nitric oxide inhalation may relieve such condition and also pain. Method: Twenty patients of SCD (Sickle Cell Disease) aged 10 years and above with acute pain admitted to Emergency Department of Apollo Hospitals, Bhubaneswar were given ‘NO’ inhalation for 6 hrs at 80 ppm. Pain was measured by Visual Analog Scale (VAS) initially and at hourly interval for 6 hrs. Results: Out of 20 cases of SCD, 18 patients responded to ‘NO’ inhalation and there was significant reduction in .. View More»
DOI:
10.4172/2329-8790.1000229