Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Bahram Delfan
West Indies
Research Article
Pretreatment of CAV Combination Chemotherapy with Tropisetron Shows Less Cardio and Neurotoxicity Side Effects in Rats
Author(s): Houman Alimoradi, Anita Barzegar-Fallah, Sanaz Mohammadi-Rick, Firouzeh Asadi, Bahram Delfan and Ahmad Reza DehpourHouman Alimoradi, Anita Barzegar-Fallah, Sanaz Mohammadi-Rick, Firouzeh Asadi, Bahram Delfan and Ahmad Reza Dehpour
Tropisetron, a 5-HT3 antagonist receptor, is commonly used for the prevention of emesis following chemotherapy. Lines of evidence point to the anti-inflammatory and immune modulatory properties of tropisetron. The current study aims to investigate whether tropisetron is able to prevent the cardiotoxicity and neurotoxicity induced by doxorubicin (DOX) and vincristine besides its anti emetic effect in a co-administration protocol, since this combination therapy is widely used in various combination chemotherapy regimens. To investigate these effects, intraperitoneal co-administration of doxorubicin and vincristine in CAV combination therapy (Cyclophosphamide, Adriamycin and Vincristine) was used to induce neuro and cardiotoxicity and in treated group tropisetron was injected 1 h prior to combination therapy. General conditions, mortality rate and body weight were measured during the exp.. View More»
DOI:
10.4172/2161-0495.S6-001