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Journal of Hematology & Thromboembolic Diseases

Journal of Hematology & Thromboembolic Diseases
Open Access

ISSN: 2329-8790

+44 20 3868 9735

Ashish Lothe

Ashish Lothe

India

Publications
  • Review Article
    Sickle Cell Disease: Current Challenges
    Author(s): Dipty Jain, Ashish Lothe and Roshan ColahDipty Jain, Ashish Lothe and Roshan Colah

    Sickle cell disease (SCD) is one of the most common monogenic diseases worldwide. Although there have been some advances in the management of SCD, much remains to be learned about the mechanisms underlying the wide phenotypic diversity of the disease. In resource poor countries, basic facilities for diagnosis and management are lacking, systematic screening is not common practice, and diagnosis is made late. Common and important morbidities associated with SCD are vaso-occlusive episodes, infections, acute chest syndrome, stroke and hip necrosis. These morbidities are often not managed effectively due to lack of proper infrastructure, expertise, and economical burden. Inadequate laboratory facilities and prenatal diagnostic services hamper proper management of disease complications as well as prevention. Newborn screening is yet to be implemented at national level in countries like India.. Read More»
    DOI: 10.4172/2329-8790.1000224

    Abstract PDF

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