Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Asfaw Debella
Ethiopia
Research Article
Assessment of Hematological, Biochemical and Histopathological Effects of
Acute and Sub-chronic Administration of the Aqueous Leaves Extract of Thymus
schimperi in Rats
Author(s): Nigatu Debelo, Mekbib Afework, Asfaw Debella, Eyasu Makonnen, Wondwossen Ergete and Bekesho GeletaNigatu Debelo, Mekbib Afework, Asfaw Debella, Eyasu Makonnen, Wondwossen Ergete and Bekesho Geleta
Background: Thymus species are widely used herbal medicinal plants for various ailments throughout the developing world Thymus schimperi. T. schimperi is one of the species that is used as spices and traditional medicine for various ailments in Ethiopia. Objective: This study was designed to assess the acute and subchronic toxic effects of the aqueous leaves extract of T. schimperi on blood parameters, histopathology and biochemicals of liver and kidney of rats. Methods: The aqueous leaves extract of T. schimperi was tested for toxicity study. Wistar rats were randomly divided into control and treatment groups. The doses for acute toxicity study were single doses of 300, 2000, 5000 and 10,000 mg/kg body weight of animal. Whereas, subchronic toxicity study daily administration of doses of 200 and 600 mg/kg of the aqueous extract were used for 90 consecutive days. Biomarkers and hematol.. View More»
DOI:
10.4172/2161-0495.1000286