Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
ISSN: 2329-8790
Asefa Gebrewold
Tanzania
Review Article
HDFx: A Recently Discovered Biologic and its Potential Use in Prevention and Treatment of Hemorrhagic Fever Viruses and Antibiotic-Resistant Superbugs
Author(s): Burton M Altura, Asefa Gebrewold and Anthony CarellaBurton M Altura, Asefa Gebrewold and Anthony Carella
Recently, we have reported on the discovery of a new, conserved protein (35-40 kDa) that protects rats, mice, guinea-pigs, and rabbits against lethal hemorrhage, endotoxins, live lethal bacterial and fungal microorganisms, and traumatic injuries when given prophylactally and therapeutically. HDFx was found to stimulate several arms of the innate immune system (e.g. macrophages, NK cells). HDFx was also found to stabilize the microcirculation, prevent rupture and leakage of postcapillary venules, prevent adhesion of platelets to endothelium and loss of platelets, stabilize falls in arterial blood pressure, and prevent stasis and pooling of blood in the postcapillary vessels, as observed by intra-vital high-resolution TV microscopy. HDFx also stimulates phagocytic uptake of foreign particulate matter and bacteria by liver Kupffer cells, splenic macrophages, and circulating macrophages. .. View More»
DOI:
10.4172/2329-8790.1000252