Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Anuradha Patel
New Jersey School of Medicine,
185 S Orange Ave, MSB E-552, Newark, NJ 07101
Tanzania
Review Article
Statins as Potentially Neuroprotective Agents: A Review
Author(s): Anuradha Patel and Sergey V PisklakovAnuradha Patel and Sergey V Pisklakov
The aim of this literature review is to assess the experimental and clinical evidence regarding potential neuroprotective effects of statins and their possible perioperative benefit. Statins are drugs used to control cholesterol disorders and prevent cardiovascular diseases by four mechanisms: improvement of endothelial function, modulation of inflammatory responses, maintenance of plaque stability, and prevention of thrombus formation. It is possible that these various effects may also be neuroprotective. The anti-inflammatory effects of statins on endothelial cell mechanisms are better understood than their role in neuroprotection or tumoral apoptosis and evidence is only just emerging that statins may be beneficial. Data regarding perioperative use of statins in neurosurgery is scarce, controversial and inconclusive since there is a lack of convincing randomized, prospective clinic.. View More»
DOI:
10.4172/2155-6148.1000251