Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Ana Riquelme
Spain
Research Article
Ischemia- Reperfusion Challenge in Human Skeletal Muscle: Study in Knee Arthroplasty Surgery
Author(s): Ana Riquelme, Martín Avellanal, Dolores Vigil, Emilio Salinero and Javier VaqueroAna Riquelme, Martín Avellanal, Dolores Vigil, Emilio Salinero and Javier Vaquero
Background: There are many studies that analyze ischemia-reperfusion injury in different organs (brain, heart...) but they are very scarce in skeletal muscle. The few studies performed in humans show partial results, and none include morphological, inflammatory, biochemical, metabolic and hemodynamic alterations. The objective of our study was to typify ischemic and ischemia-reperfusion injury in skeletal muscle in patients undergoing total knee arthroplasty from several points of view: morphological, biochemical, metabolic and hemodynamical, as well as to evaluate the protective effect of a single-dose of corticoids on the above-mentioned parameters.
Methods: Forty-one patients participated in the study. They were randomly assigned to either group A: no corticoid administered; or to group B: a single dose of methylprednisolone was administere.. View More»
DOI:
10.4172/2155-6148.1000178