Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Amit Joshi
India
Review Article
Differential Diagnosis of Thrombocytopenia in Hematopoietic Stem Cell Transplant Patients
Author(s): Preeti Chavan, Bharat Chauhan, Amit Joshi, Shashank Ojha and Vivek BhatPreeti Chavan, Bharat Chauhan, Amit Joshi, Shashank Ojha and Vivek Bhat
Thrombocytopenia has remained a major concern in post-haematopoietic stem cell transplant patients. It is a strong negative indicator for survival and is often seen in patients with advanced acute and chronic Graft versus host disease (GVHD). The pathogenesis of thrombocytopenia varies from impaired thrombopoiesis to increased turnover of platelets. The dose of CD34+ cells and that of megakaryocyte specific lineage cells (CD34+ /CD41+ and CD34+ / CD61+ ) has a positive effect on thrombopoiesis. Conditions like bone marrow fibrosis, CMV infection and ganciclovir administration affect the bone marrow environment leading to ineffective thrombopoiesis. Increased destruction of platelets is seen with GVHD, drugs, infections, thrombotic microangiopathy and platelet refractoriness due to alloimmunization. The management of thrombocytopenia includes treating the underlying conditions and supp.. View More»
DOI:
10.4172/2329-8790.1000168