Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Ames Paul RJ
Queen Mary University Hospital London and St George’s Hospital NHS Trust,
London
United Kingdom
Case Report
Severe Thromboembolism and Systemic Lupus Erythematosus Developing after Ovarian Hyperstimulation in a Persistent Carrier of Antiphospholipid Antibodies
Author(s): Grandone Elvira, Orefice Giuseppe, Jose Delgado Alves and Ames Paul RJGrandone Elvira, Orefice Giuseppe, Jose Delgado Alves and Ames Paul RJ
Ovarian hyperstimulation (OH) is not a contraindication in selected women with antiphospholipid syndrome and/or systemic lupus erythematosus (SLE). A young woman who was persistently positive antiphospholipid antibodies, low protein free S and homozygous for the paraoxonase G192A mutation underwent three courses of OH; after the fourth course she developed severe thromboembolism and clinical features of SLE despite the use of a gonadotropin-releasing hormone agonist alongside aspirin that should have minimised the risk of OH syndrome. We provide a pathogenetic interpretation of these events in the light of the patient’s investigations... View More»
DOI:
10.4172/2329-8790.1000150