Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Ali Akbar Morabi
West Indies
Research Article
The Effect of Pre-operative Oral Clonidine or Gabapentin on Post-operative Pain intensity, Morphine Consumption and Post-operative Nausea and Vomiting in Patients Who Undergone Thyroidectomy: A Double-blind Placebo-control Study
Author(s): Seyed Mojtaba Marashi, Ali Akbar Morabi, Mohammad Hossein Ghafari, Omid Azimaraghi and Ali MovafeghSeyed Mojtaba Marashi, Ali Akbar Morabi, Mohammad Hossein Ghafari, Omid Azimaraghi and Ali Movafegh
Background: This prospective, randomized, double-blind study evaluated the effect of clonidine and gabapentin premedication on postoperative pain intensity, morphine consumption, nausea and vomiting. Methods: Sixty-six ASA I-II patients, aged 20 to 55 were randomly allocated to orally receive either clonidine 0.2 mg (group C,n=22), placebo (group P,n=22) or gabapentin 900 mg (group G, n=22) two hours before operation. Postoperative visual analog scale for pain (VAS), nausea and vomiting were measured in the recovery room and 2,6,12 and 24 hours following the surgery as well. Results: The patients’ characteristics were alike in three groups. The VAS pain scores at measured times were significantly lower in the clonidine (3.4 ± 0.9, 4.2 ± 0.75, 4.8 ± 1.0, 4.9 ± 1.3, 3.3 ± 0.6) and gabapentin groups (3.1 ± 0.6, 4.1 ± 1.0, 3.6 ±.. View More»
DOI:
10.4172/2155-6148.1000206