Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
+44 1223 790975
ISSN: 2155-6148
+44 1223 790975
Aldo Saad Diab
Department of Anesthesiology, Hospital Miguel Perez Carreno, Caracas,
Venezuela
Research Article
Evaluation of the Effect of Dexmedetomidine on the Suppression of the Adrenergic Response to Laryngoscopy and Intubation
Author(s): Danilo Nava, Juan Carlos Núñez, Betzabeth Hernandez, Andilay Pota Barito and Aldo Saad DiabDanilo Nava, Juan Carlos Núñez, Betzabeth Hernandez, Andilay Pota Barito and Aldo Saad Diab
Objectives: Dexmedetomidine is a potent agonist of α-2 receptors with sympatholytic, sedative and analgesic properties. Direct laryngoscopy and endotracheal intubation are associated with hemodynamic changes due to reflex sympathetic discharge; causing hypertension, tachycardia and arrhythmias. Several drugs have been used to control this haemodynamic response however, none harmless.
Materials and methods: Sample of 60 patients, divided into two groups, the DM1 group received a dexmedetomidine dose of 0.5 μg/kg, and the DM2 group received a dose of 1 μg/kg of the same drug diluted in 100 cc of solution, which it was administered in 10 min. The hemodynamic variables (HR, SBP, DBP and MAP) and sedation during two periods were verified.
Results: In the first stage there was a decrease in the SBP in the DM1 .. View More»
DOI:
10.4172/2155-6148.1000828