Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Research Article
Propofol vs. Ketofol for Endoscopic Retrograde Cholangiopancreatography (ERCP) Bi-Spectral Index (BIS) Guided Sedation: A Randomized Clinical Trial
Author(s): Eman Sayed Ibrahim, Emad Kamel Refaat, Alaa Eldin Abd Elsami Aiad, Eman Ahmed Fathy and Osama Abdullah EL SharkawyEman Sayed Ibrahim, Emad Kamel Refaat, Alaa Eldin Abd Elsami Aiad, Eman Ahmed Fathy and Osama Abdullah EL Sharkawy
Objective: Sedation for ERCP with propofol related adverse events (SRAES) includes hypotension, arrhythmia, oxygen desaturation, unplanned intubation and procedure termination. The aim of this study was to evaluate the effect of adding a small synergistic dose of ketamine to propofol (Ketofol) vs. propofol alone.
Methods: 80 adults (ASAI-II) scheduled for elective ERCP categorized into Ketofol (KP) (n=40) and Propofol (P) (n=40) groups. In Propofol (P) group, 1.5 mg/kg over 3-5 min then 50-75 mic/kg/min guided by BIS (≥60). In KP group: 1.5 ml/kg of (Propofol 1%+Ketamine (50 mg)+4 ml normal saline) over 3-5 min then 50-75 mic/kg/min. Nasal airway after sedation. Induction and recovery time, Propofol consumption, haemodynamics, pain assessment, nausea and vomiting were recorded post-operative.
Results: Total dose .. View More»