Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Abdelaziz M. Hussein
Egypt
Research Article
Cardiovascular Toxic Effects of Chlorpyrifos: A Possible Protective Role for Pomegranate Extracts
Author(s): Azza M. El-Wakf, El-Sayed M. El-Habibi, Nashwa M. Barakat, Afaf M. Attia, Abdelaziz M. Hussein and Intisar I. AliAzza M. El-Wakf, El-Sayed M. El-Habibi, Nashwa M. Barakat, Afaf M. Attia, Abdelaziz M. Hussein and Intisar I. Ali
Objectives: Present study aimed to investigate if prolonged intake of either pomegranate peel methanolic extract (PPME) or pomegranate juice (PJ) could protect against CPF-induced cardiotoxicity and restore cardiac functions up to normal status.
Methods: Thirty six male albino rats (170-180 g) were equally allocated into 6 groups, the first four ones were used as control, PJ (3 ml/kg), PPME (200 mg/kg) and CPF (6.75 mg/kg) groups, while the two last groups were given CPF+PJ and CPF+PPME at the same mentioned doses, daily for 60 successive days.
Results: CPF-exposed group showed electrocardiograph (ECG) alterations, manifested as ST segment elevation, prolonged corrected QTc interval and shortened RR interval, along with elevation in heart rate and blood pressure. Further elevation in cardiac marker enzymes (CK-MB, LDH) a.. View More»
DOI:
10.4172/2161-0495.1000374