Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Aaron V. Riley
Tanzania
Research Article
Elevated Biochemical Markers of Myocardial Injury are not Associated with Postoperative Cognitive Dysfunction after Coronary Artery Surgery
Author(s): Judith A. Hudetz, Oludara Amole, Aaron V. Riley, Kathleen M. Patterson and Paul S. PagelJudith A. Hudetz, Oludara Amole, Aaron V. Riley, Kathleen M. Patterson and Paul S. Pagel
Background: The systemic inflammatory response to cardiopulmonary bypass (CPB) and organ hypoperfusion during CPB contribute to cerebral and myocardial dysfunction in patients undergoing cardiac surgery. We hypothesized that biochemical markers of myocardial injury [creatine kinase - myocardial band (CK-MB), troponin-I] may be independently associated with postoperative cognitive dysfunction (POCD; an indicator of cerebral dysfunction) in patients undergoing coronary artery bypass graft (CABG) surgery using CPB.
Methods: Eighty-eight age- and education-balanced patients=55 years of age undergoing elective CABG with CPB and 28 nonsurgical controls with coronary artery disease were enrolled. Recent verbal and nonverbal memory and executive functions were assessed before surgery, 1 week, and 3 months after surgery using a standard psychometric .. View More»
DOI:
10.4172/2155-6148.1000134