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Fluorouracil (5-FU) is an anticancer medicine that works by slowing or stopping cell growth. The medicine interferes with the ability of abnormal cells to grow on the skin's top layer. It is used normally for Colon and rectal cancer, Breast cancer,Gastrointestinal cancers including: anal, esphageal, pancreas and gastric (stomach), Head and neck cancer. 5-FU is a Pyrimidine antagonist, belongs to the category of chemotherapy called antimetabolites. Antimetabolites are very similar to normal substances within the cell. When the cells incorporate these substances into the cellular metabolism, they are unable to divide. Antimetabolites are cell-cycle specific, Pyrimidine antagonist Serious adverse reactions to 5-FU are; chest pain, EKG changes and increases in cardiac enzymes – which may indicate problems with the heart. These symptoms are very rare but increased for patients with a prior history of heart disease.
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