Pediatrics & Therapeutics
Open Access

Updates in preserving reproductive potential of pre-pubertal girls with cancer

International Conference and Exhibition on Pediatric Oncology and Clinical Pediatrics

August 11-13, 2016 Toronto, Canada

Mahmoud Salama

University of Cologne, Germany

Posters & Accepted Abstracts: Pediat Therapeut

Abstract :

With increasing numbers of adult female survivors of childhood cancers due to advances in early diagnosis and treatment, the issue of preserving the reproductive potential of prepubertal girls undergoing gonadotoxic treatments has gained greater attention. Unfortunately, the two established fertility preservation options, embryo freezing and egg freezing, cannot be offered routinely to prepubertal girls as these options necessitate prior ovarian stimulation and subsequent mature oocytes retrieval that are contraindicated or infeasible before puberty. Therefore, the most suitable fertility preservation options to prepubertal girls are (1) ovarian tissue freezing and autotransplantation, (2) in vitro maturation, and (3) ovarian protection techniques. In this presentation, those fertility preservation options as well as their success rates, advantages, disadvantages and future directions will be discussed in detail. Also a new integrated strategy to preserve the reproductive potential of prepubertal girls with cancer will be highlighted. Although experimental, ovarian tissue slow freezing and orthotopic autotransplantation may be the most feasible option to preserve the reproductive potential of prepubertal girls with cancer. However, this technique has two major and serious disadvantages: (1) the risk of reintroducing malignant cells and (2) the relatively short lifespan of ovarian tissue transplants. Several medical and ethical considerations should be taken into account before applying this technique to prepubertal girls with cancer.

Biography :

Email: eaims_gm@yahoo.com