Hongwu Zeng, Camille Garcia Ramos, Veena A Nair, Yan Hu1, Jianxiang Liao, Christian La, Li Chen, Yungen Gan, Feiqiu Wen, Bruce Hermann and Vivek Prabhakaran
Shenzhen Children’s Hospital, China
University of Wisconsin, USA
Posters & Accepted Abstracts: Pediat Therapeut
Objective: The purpose of this study was to investigate regional homogeneity (ReHo) in children with new-onset drugnaive Benign Epilepsy with Centrotemporal Spikes (BECTS), chronic BECTS and Healthy Controls (HC) using the Regional Homogeneity (ReHo) method applied to resting state fMRI data. Methods: Resting state fMRI data was collected from three groups of children aged 6 to 13, including new onset drug naive BECTS, chronic BECTS with medication and HC; the data analyzed by ReHo method. Mandarin school exams scores were acquired and compared across groups. Results: There were three main findings. Firstly, compared with HC, abnormally increased ReHo was observed in bilateral sensorimotor regions in new onset BECTS which normalized or even reversed in the chronic BECTS group. Secondly, enhanced ReHo was found in the left frontal language region in the two BECTS groups with even higher ReHo value in the chronic group. Lastly, decreased ReHo was found in regions of the default mode network (DMN), bilateral occipital lobes and cerebellum in both the new onset and chronic BECTS groups, lower in chronic BECTS. Behavioral analyses of school scores showed the chronic BECTS group got lower scores compared to HC with to statistically significant difference (p<0.05). Conclusion: The coherence of low frequency fluctuations is disrupted in sensorimotor, language and DMN in new-onset BECTS. Some of these effects seem to be selectively normalized in chronic BECTS, thus allowing us to explore possible chronicity and AED-induced effects on BECTS. Abnormal ReHo in left language and DMN regions could be responsible for impairments of cognitive function.
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