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Quantitative repolarization differences predict Kawasaki disease | 28869
Pediatrics & Therapeutics

Pediatrics & Therapeutics
Open Access

ISSN: 2161-0665

+44 1478 350008

Quantitative repolarization differences predict Kawasaki disease while atrio-ventricular depolarization differences predict coronary artery anomalies


International Conference and Exhibition on Pediatric Cardiology

August 25-27, 2015 Valencia, Spain

Daniel Cortez, Sonali Patel, Bruce Landeck, Anthony C McCanta and Pei-Ni Jone

University of Colorado School of Medicine, USA

Posters-Accepted Abstracts: Pediat Therapeut

Abstract :

Introduction: Kawasaki disease (KD) is the leading cause of acquired heart disease in children. 12-lead electrocardiogram (ECG) changes in patients during the acute phase of KD include flattened T-waves and prolonged corrected QT-intervals (QTc). We set out to determine the most accurate 12-lead ECG and VCG predictors for identification of patients with KD and which of these predictors would be clinically useful for early identification of those with coronary artery anomalies (CAA). Methods: A blinded, retrospective case control study of patients with KD and age-/gender-matched controls was performed. Deep Qwaves, corrected QT-intervals (QTc), spatial QRS-T angles, principle T-wave component vector (RMS-T) and spatial P-R angles (SPR angles) were assessed. Student t-tests, Chi square and Analysis of Variance were used to identify significant differences between groups Results: Fifty patients with KD (mean age 3.1�?±3.1 years, 26% female) were compared to fifty control patients (mean age 3.8�?±2.9 years, 44% female). Of the KD patients, 32 (64%) were diagnosed as atypical KD and 28 (56%) of them had CAA. KD patients were significantly differentiated from control patients by deep Q waves (72% vs. 44% p=0.005), QTc values (395.1�?±24.7ms vs. 410.4�?±34.7 ms, p=0.013), and the RMS-T (4.2�?±0.2dmV vs. 6.3�?± 0.3 dmV pâ�?¤0.001) respectively. Atypical KD was also discriminated from controls with an odds ratio or 22.3. The spatial P-R angle significantly discriminated CAA from those without. Conclusion: The RMS-T differentiates KD is typical or atypical from controls. Kawasaki patients with coronary artery anomalies were differentiated from those without coronary changes by the SPR angle.

Biography :

Email: dr.danielcortez@gmail.com

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