Pediatrics & Therapeutics
Open Access
ISSN: 2161-0665
ISSN: 2161-0665
Po-Nien Tsao
National Taiwan University, Taiwan
Posters & Accepted Abstracts: Pediat Therapeut
Preeclampsia, respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are associated with dysregulation of vascular growth factors, especial for vascular endothelial growth factor (VEGF) and placental growth factor (PlGF). However, the relationship between maternal preeclampsia and RDS, BPD or ROP in preterm infant��?s posses a degree of variability and the issue remains controversial. Therefore, we conducted a large population-based cohort of very low birth weight (VLBW) infants to analyze these relationships. Total 6,000 VLBW infants were included for analysis. Infants with maternal preeclampsia had a higher gestational age, higher incidence of cesarean section and being small for their gestational age, lower incidence of patent ductus arteriosus and sepsis. Both RDS and BPD occurred significantly less frequently in the maternal preeclampsia group, however, the multivariate logistic regression analysis revealed maternal preeclampsia was negatively associated with the risk of developing BPD, but has no effect on the incidence of RDS. Subgroup analysis showed that the association between preeclampsia and BPD was significant only in those VLBW infants with a gestational age between 31��?34 weeks. Similar to RDS and BPD, the incidence of ROP was also significantly lower in infants with maternal preeclampsia than in those without maternal preeclampsia. Multivariable logistic analysis, which included the variables that were significant according to univariable analysis, showed that the preeclampsia was not associated with all grade ROP.
Email: tsaopn@gmail.com