Journal of Chromatography & Separation Techniques
Open Access

Metabolomics study of the fruits of Alpinia oxyphylla as an effective treatment for chronic renal injury in rats

3^rd International Conference on Mass Spectrometry

October 10-11, 2016 Kuala Lumpur, Malaysia

Y H Li

Hainan Medical University, China

Scientific Tracks Abstracts: J Chromatogr Sep Tech

Abstract :

Alpinia oxyphylla (Zingiberaceae) is a well-known medicinal plant. Its fruit (â�?�?Yi-Zhi-Renâ�? in Chinese) is used as an anti-diuretic and traditionally used for the treatment of enuresis and reduce urination. Chronic kidney disease (CKD) is a disease with the characteristic of the slowly loss of kidney function and has a prevalence of up to 7-10% in adults. Recent advances in its etiology and pathogenesis are providing more speculative hypotheses focused on integral systems. Using a UPLCâ�?�?QTOF-MS/MS-based metabolomics platform, we explored the changes of metabolic profiling in plasma/urine simultaneously between chronic kidney disease (CKD) induced from adenine excess and the protective effects of A. oxyphylla extract (AOE). The total 21 metabolites (12 in urine and 9 in plasma), up-regulated or down regulated, were identified and contributed to CKD progress. Among these biomarkers, agmatine, CAMP, 7-methylguanine, hippuric acid, indoxyl sulfate, asparagines, kynurenic acid and p-cresol sulfate were restored back to the control-like level after the treatment of AOE (p<0.05 or 0.01), these findings may be promising to yield a valuable insight into the pathophysiology of CKD and serve as characteristics to explain the mechanisms of AOE.

Biography :

Y H Li has completed his MD from Shanghai Institute of Pharmaceutical Industry and Post-doctoral studies from China Academy of Chinese Medical Sciences. He has published more than 20 papers in reputed journals.

Email: lyhssl@126.com