Pediatrics & Therapeutics
Open Access
ISSN: 2161-0665
+44 1478 350008
ISSN: 2161-0665
+44 1478 350008
Kris Lodrono
University of the Philippines-Philippine General Hospital, Philippines
Posters & Accepted Abstracts: Pediat Therapeut
Objectives: The varying conclusions regarding the utility of albumin in improving outcomes have precluded the consistent use of albumin infusions in gastroschisis. This study aimed to determine the association of albumin infusion and mortality among neonates with gastroschisis admitted in a tertiary government hospital. Methodology: This was a retrospective cohort study on neonates with gastroschisis admitted from January 2009 to December 2013. A total of 39 records were reviewed and baseline characteristics were described. An association between albumin infusion status and each of the following outcomes were described: length of hospital stay, incidence of at least one complication and mortality. Results: The results are comparable to earlier studies in that majority had low birth weights, were early term births to young mothers. Most underwent two-stage repair and had hypoalbuminemia. Most (59%) had albumin infusions given postoperatively. Significant differences were noted between neonates given albumin and those who were not given albumin infusions in terms of hospital stay (median Pearson Chi p value 0.027) and the incidence of at least one complication (crude odds ratio 13.2, 95%CI 1.25 ��? 633.87). There is no significant difference in terms of mortality (crude odds ratio 0.24, 95%CI 0.005 ��? 2.58). Conclusion: Human albumin infusion was significantly associated with increased length of hospital stay and higher incidence of at least 1 complication, but with no significant decrease in mortality. However, the small number of data limits further analysis for confounders and modifiers. Larger prospective studies are recommended to further describe these associations.
Email: krishalodge@gmail.com