Journal of Chromatography & Separation Techniques
Open Access

Formulation excipients (The good, the bad and the ugly)

International Summit on Current Trends in Mass Spectrometry

July 13-15, 2015 New Orleans, USA

Vijayabhaskar Veeravalli

Posters-Accepted Abstracts: J Chromatogr Sep Tech

Abstract :

Formulation excipients are used at high concentrations in preclinical formulations to solubilise NCEs of varying lipophilicities. The good (Measuring plasma concentrations of formulation excipient acts as quality control check for in vivo PK studies), the bad (Matrix effects arising from formulation excipients cause differential ionisation between calibration standards and study samples, producing false concentration levels) and the ugly (altered pharmacokinetic parameters resulting in false positive and false negatives) aspects of using formulation excipients in preclinical formulations will be discussed in detail. Bioanalytical approaches to identify and nullify the matrix effects will also be presented.