Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
ISSN: 2157-7064
Jyothi Penta, Mohd Zahed Mohiuddin and D V Ratnam
Chaitanya College of Pharmacy Education and Research, India
Posters-Accepted Abstracts: J Chromatogr Sep Tech
The intention of present investigation is to develop the glyburide liquisolid compacts containing varying amounts of carrier and coating materials to enhance the bioavailability of glyburide when compared to conventional tablets. MCC or Avicel pH 101/102 as carrier and Aerosil as the coating material are selected for the preparation of liquisolid compacts. Liquisolid technique is a new and promising method that can change the dissolution rate of drugs. This technique of liquisolid preparation is used to formulate drug solution in solid dosage form. From the in vitro drug release studies the optimized formulation F6 showed 92.57�?±0.54% drug release in 10 min where as the conventional tablets showed 23.87�?±1.13% in 10 min. The F6 formulation showed 9.25% /min initial dissolution rate, 2.14 relative dissolution rate and 67.52 dissolution efficiency. When compared to conventional tablets, dissolution efficiency increased by 4.5 times in optimized formulation F6. From the above results, it can be inferred that the liquisolid technique increases the wetting properties and surface area of glyburide drug particles by changing their properties achieved by dispersing the drug particles in a non-volatile liquid vehicle. It showed that there are no interactions between the drug and excipients. Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared Spectroscopy (FTIR) studies revealed that there was no interaction between drug and polymer. In conclusion, liquisolid technology was successful in improving bioavailability of glyburide.
Email: jyothispartan@gmail.com