Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
+44 1300 500008
ISSN: 2157-7064
+44 1300 500008
Raafat A Mandour
Mansoura University, Egypt
Posters & Accepted Abstracts: J Chromatogr Sep Tech
Background & Aim: Drug toxicology tests are most commonly performed on urine, since most drugs and
their breakdown products are excreted in the urine at higher concentration. The aim of this work is to evaluate
the usefulness of using urine immunoassay kits for detection of some drugs of abuse, and study the correlation
between the results obtained by EMIT and GC/MS techniques.
Materials & Methods: A total number of 449 inhabitant urine samples were collected from patients admitted
to emergency hospital, Mansoura University. A total of 449 urine samples were analyzed by EMIT and GC/
MS for benzodiazepine, barbiturate, opiate and cannabinoid.
Results: Obtained results revealed that urine immunoassay kit is useful for rapid preliminary screening of
abuse drug. GC/MS results confirm that 245 samples (54.56%) are positive of the total number of samples.
These positive samples by GC/MS were as follows- benzodiazepines: 159 ((clonazepam, oxazepam,
temazepam), barbiturates: 58 (thiobarbiturate, butabarbital, seconal) and opiates: 28 (methadone metabolite)).
Conclusions & Recommendations: GC/MS analysis must be done for accurate identification and
confirmation of EMIT results. Also, it is recommended as the most suitable technique for obtaining optimum
analytical results.