Diabetic ketoacidosis in children and adolescents with newly diag | 60153
Pediatrics & Therapeutics

Pediatrics & Therapeutics
Open Access

ISSN: 2161-0665

+44 7868 792050

Diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in Tigray, Ethiopia: retrospective obser vational study

3rd International Conference on Pediatric Pharmacology and Therapeutics

October 22, 2021 | Webinar

Dr. Fikaden Berhe

Mekelle University College of Health Sciences, Tigray, Ethiopia

Scientific Tracks Abstracts: Pediatr Ther

Abstract :

Background: Diabetic ketoacidosis (DKA) is the most severe acute complication of type 1 diabetes mellitus which results in increased risk of morbidity and mortality especially in developing countries. Objective: To assess prevalence and associated factors of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in hospitals of the Tigray region, Ethiopia. Methods: A facility based retrospective observational study design was conducted in newly diagnosed type 1 diabetic children and adolescents up to the age of 18 years who were registered in 13 general and two referral hospitals from January 1, 2013 to December 30,2017. The diagnosis of diabetic ketoacidosis was made with the criteria below, Children presenting with polysymptoms, weight loss, vomiting, dehydration, and also the indirectsigns or effects of acidosis on respiratory and central nervous systems like Kussmaul breathing, lethargy or coma and biochemically random blood sugar level >11 ml/L, gluco-suria and urine ketone >+1 and diagnosed with type 1 diabetes for the first time. Descriptive, Mann –Whitney U and logistic regression analysis were carried out to describe and identify the associated factors with diabetic ketoacidosis. Results: More than three-quarters, 258/328 (78.7%) of the newly diagnosed type 1 diabetes patients, presented with diabetic ketoacidosis at initial diagnosis. Median age of diabetic ketoacidosis patients was 11 years. The patients with diabetic ketoacidosis were younger than nondiabetic ketoacidosis patients (11 vs. 13 years, P =0.002). The mortality rate of diabetic ketoacidosis was 4.3%. Young age, presence of precipitating factors and symptoms of DKA/ diabetes were found to be highly associated with diabetic ketoacidosis at initial diagnosis. Conclusions: The prevalence of diabetic ketoacidosis was alarmingly high. The case fatality rate was significant high. Young age group patients, precipitating factors and the presence of symptoms of diabetes/DKA like excessive drinking, vomiting and fatigue were highly associated with diabetic ketoacidosis.

Biography :

Dr.Fikaden Berhe has obtained her medical degree at Mekelle University ,College of Health sciences in Ethiopia. she finished her residency in Paediatrics and child health department in the same university, she was the most dedicated, influential , top scorer chief resident. She has eight years’ experience in paediatrics, with special interest in paediatrics endocrinology. she is also involved in research works, she has worked as a head of department of paediatrics and child health for one year. Dr.Fikaden is local tutor for the Sydney child health Program in Mekelle and also she is an honorary associate of University of Sydney.