Correlation between the warfarin dose and maternal and fetal outc | 22188
Pediatrics & Therapeutics

Pediatrics & Therapeutics
Open Access

ISSN: 2161-0665

Correlation between the warfarin dose and maternal and fetal outcomes in pregnant women with prosthetic heart valves

International Conference on Pediatrics & Gynecology

6-8 December 2011 Philadelphia Airport Marriott, USA

Z. Nene and P Soma-Pillay

Accepted Abstracts-2011: Pediatr Therapeut

Abstract :

This study was conducted on 321 hypertensive young patients aged 18-35 years in which we found 28 cases of coarctation of the aorta from pregnant women, representing 8.73% as a cause of hypertension, the disease being undiagnosed up to that point and hypertension were initially erroneously interpreted as gestational hypertension. Objective: Th e main objective of this study was to identify which are the main diseases underlying the etiology of hypertension in young and this opportunity has been surprisingly discovered a congenital heart malformation - coarctation of the aorta - previously undiagnosed at hypertensive pregnant women, with contraindication for pregnancy. Design / Methods: Th e study is the fi rst complex longitudinal study of Romania at Bihor county level, for a period of three years between 2006 - 2009, on a lot of 321 hypertensive young patients, with aged 18-35 years, with values of BP>140/90mmHg persisted at three repeated measurements, to exclude white coat phenomenon very common in young or who had a severe value of BP>170-100mmHg from the fi rst determination, at which has been identifi ed the etiology of hypertension by clinical and complex laboratory investigations. Th e statistical analysis was done with the help of EPIINFO, the version 6.0, program of the Control and Prevention Center of Disease - CDC (Center of Disease Control and Prevention) of Atlanta, adapted processing of medical statistics. Were calculated parameters averages, frequency intervals, standard deviations, tests of statistical signifi cance by Student method (t test) and χ�. Th e test t called Student test take into account the standard deviation of the sample. Results: From the lot of 321 young hypertensive patients studied, 15.27% had renal artery stenosis, 12.47% - glomerulonephritis aft er β hemolytic streptococcal infection, 5.29% - polycystic kidney, 4.36% - diabetic nephropathy, 2.49% - hypoplasic kidney, 1.27% - primary reninom, 5.60% - pheochromocytoma, 3.43% - Conn disease, 4.90% - hyperthyroidism, 2.80% - Cushing?s syndrome, 9.03% - X metabolic syndrome, 2.80% - use oral contraceptives, 2.53% - consumption of NSAID and prednisone drugs, 1.55% - use of anabolic steroids, 8.73% - coarctation of the aorta and 17.40% - essential hypertension. Mention that the percentage of 8.73% of cases of coarctation of the aorta was diagnosed in pregnant women, at which has escaped previous diagnosis of pregnancy and hypertension was initially interpreted in the context of pregnancy. Conclusions: Coarctation of the aorta is a congenital heart disease witch evolving with cardiovascular secondary hypertension. Undiagnosed at time, early postpartum or in childhood can be very risky later in women, because pregnancy can aggravate hypertension and may be misinterpreted as gestational hypertension, having regard to the real diagnosis of coarctation of the aorta, which may worsen the prognosis of the patient, especially since in the pregnancy may appear innocent heart murmurs and that makes it diffi cult to interpret murmur heart at cardiac auscultation. Hypertension during pregnancy is an important issue, primarily through the consequences that may occur to the fetus and secondly by not considering other causes of secondary hypertension in young women, some of them even contraindication further development of pregnancy, such as coarctation of the aorta. Evolution of hypertension by coarctation of the aorta can be severe if the lesion is close. In addition to the occurrence of childhood and adolescence, hypertension may be complicated by bacterial endocarditis, aortic rupture and haemoperitoneum (especially during pregnancy) on fund of abdominal aortic aneurysm - with which it can coexist not known previously diagnosed, dissecting aneurysm of aorta and cerebral hemorrhage (when coarctation associated with cerebral aneurysms) with vital risk of sudden death.

Biography :

Manuela Stoicescu, MD Internal Medicine, PhD, assistant Professor of University of Oradea, Faculty of Medicine and Pharmacy Ora dea, Romania, Medical I Department, 1 Decembrie No. 10 Avenue: Phone 0723019951, e-mail: Home address: Republicii , No. 49, Ap. 7 Avenue, Oradea City, Romania Country, Code post: 410167