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Comparative pharmacokinetics of five cimicifugosides in dogs and | 52241
Journal of Chromatography & Separation Techniques

Journal of Chromatography & Separation Techniques
Open Access

ISSN: 2157-7064

+44 1300 500008

Comparative pharmacokinetics of five cimicifugosides in dogs and rats after oral administration of Cimicifuga foetida L. extract


International Summit on Current Trends in Mass Spectrometry

July 13-15, 2015 New Orleans, USA

Yinglin Wang1, Chunjie Sha2, Wanhui Liu2,3 and Quan Zhao1

Posters-Accepted Abstracts: J Chromatogr Sep Tech

Abstract :

Cimicifuga foetida L., a traditional Chinese medicine, has been developed for the treatment of women with menopausal syndrome in China (Brand name: XIMINGTINGR, XMT). The purpose of this study was to reveal the preclinical pharmacokinetics characteristic of this drug by comparing the pharmacokinetics of five main cimicifugosides (cimicifugoside H-2, cimicifugoside H-1, 23-epi-26-deoxyactein, cimigenol xyloside and 25-O-acetylcimigenoside) obtained from XMT in dogs and rats after oral administration with three doses respectively. The plasma concentrations of five cimicifugosides in both dogs and rats were determined by using an established high-performance liquid chromatography (HPLC) coupled with tandem mass spectrometry quantitative detection method. The pharmacokinetics parameters were estimated by WinNonLin software. The absorption feature of these cimicifugosides in plasma was almost similar between dogs and rats. There were significant differences in the pharmacokinetics properties among these cimicifugosides in dogs and rats. Among the five cimicifugosides, cimigenol xyloside showed the slowest elimination whereas cimicifugoside H-2 was the fastest in both dogs and rats. The values of AUC of cimigenol xyloside were the largest whereas those of cimicifugoside H-2 were the smallest in both dogs and rats. The higher concentrations of five cimicifugosides in liver after oral administration in rats showed that cimicifugosides was mainly accumulated in liver, however, limited distribution to the brain, indicated that cimicifugosides may have difficultly penetrating the blood brain barrier.

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