Pediatrics & Therapeutics
Open Access
ISSN: 2161-0665
+44 1478 350008
ISSN: 2161-0665
+44 1478 350008
Lebedev Vyacheslav Vyacheslavovich, Demikhov V G, Zhurina O N, Fomina M A and Dmitriev A V
Ryazan State Medical University, Russia
Posters & Accepted Abstracts: Pediatr Ther
The question of comparative effi cacy and safety of preparations of iron remains the subject of discussions. 46 children aged 6 months to 17 year were included in our study: 24 children received ferrous sulfate II, 22 children received hydroxidepolymaltose complex (HPC) of iron III. Th ese groups were comparable by severity of anemia, age and sex. In addition to effi cacy, the degree of toxicity of iron preparations was determined (the number of adverse events, the level of carbonyl derivatives). Aft er 3 months of ferrotherapy, the average Hb concentration in children received iron II sulfate was higher in comparison with children taking HPC III (13.16�?�?�?±0.284 g/dL in the iron II sulfate group against 12.1�?�?�?±0.394 g/dL in the group of HPC III (p=0.033). But increase Hb level more 1.0 g/dL in 1 month of ferrotherapy were observed in both groups. Aft er 3 months of therapy, the average serum ferritin concentration was higher in the group of patients taking iron sulfate (24.0�?�?�?±2.95 �?�?�?¼g/l vs. 13.47�?�?�?±1.6 �?�?�?¼g/l, respectively) (p=0.003). Th e undesirable eff ect of oral ferrotherapy were detected in 11 (45.8%) of patients taking ferrous sulfate II and in 3 (13.6%) patients taking HPC III (p=0.014). For the fi rst time, an assessment of the toxicity of preparations was carried out using the method of integrated evaluation of oxidative modifi cation products of proteins products. We have shown that iron preparations lead to the development of oxidative stress, which is more pronounced when using ferrous sulfate II.
Lebedev Vyacheslav Vyacheslavovich has graduated from the Ryazan State Medical University in 2013. In 2014, he has completed his Internship in the specialty Pediatrics. Presently he is a full-time Postgraduate student of the Pediatrics Department with the course of Pediatric Surgery.