Journal of Chromatography & Separation Techniques
Open Access
ISSN: 2157-7064
ISSN: 2157-7064
Maryam Salimi
Tehran Province Water and Waste water Company, Iran
Scientific Tracks Abstracts: J Chromatogr Sep Tech
In this study, a simple, efficient and reliable HPLC method was developed for determination of ibuprofen and diclofenac belong to group of Painkiller and anti-inflammatory drugs in wastewater influents and effluents from WWTP. The method involves pre-concentration and clean-up by solid phase extraction (SPE). Final analysis of the selected pharmaceutical compounds was carried out by high-performance liquid chromatography (HPLC) on a reversed- phase C18 column using by gradient elution with methanol , acetonitrile and a 0.05 M phosphate-buffer (pH=4.5) at a flow-rate of 1 ml min-1 with diode array detector (DAD). The recoveries for all samples were more than 70%. The calibration curves obtained for studied drugs show reasonable linearity (R2 > 0.99) and the Limits of quantification were 0.05 ng ml-1 and 0.1 ng ml-1for ibuprofen and diclofenac, respectively. The described method was applied to the determination of the drugs in wastewater samples from WWTP in the south of Tehran.
Maryam Salimi has a lot of experience in method development and validation by miniaturization and simplification of sample-preparation procedures and analytical techniques such as, HPLC , GC instrumentation, spectroscopic and their corresponding methods that have been applied in the analysis of pharmaceuticals and water samples. she worked (2000-2006)as analytical chemist in QC laboratory of pharmaceuticals and worked (2006-2018) as researcher and analytical chemist in organic laboratory of water and wastwater company
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