Journal of Hematology & Thromboembolic Diseases
Open Access

Bone Homeostasis

Calcium homeostasis regulates calcium flow to and from the bones. Inadequate calcium levels can result in osteoporosis. Calcium release from bone is regulated by parathyroid hormone. Vitamin D is converted to calcidiol (also called calcifediol)
in the liver, which is then converted to calcitriol in the kidneys, the biologically active form of vitamin D. Calcitriol regulates the levels of calcium and phosphorus in the blood and helps maintain a healthy skeletal system. Bone resorption by osteoclasts releases calcium into the bloodstream, which helps regulate calcium homeostasis.