Department of Experimental Medicine
University of Campania, Naples, Italy
Dr. Dario Siniscalco is Research Associate for the Department of Experimental Medicine of the Second University of Naples (SUN), Italy. He graduated in Chemistry from the University of Naples “Federico II” in 2000 and received his Ph.D. in Pharmacological Sciences from SUN in 2004. He completed his neuropathology fellowship at University of Alabama at Birmingham, USA before joining the Second University of Naples staff in 2006. He is registered member of the following scientific societies: Order of the Chemists of Campania, National Council for Chemistry, Stem Cell Research Italy, International Association of Neurorestoratology, and European Association for Chemical and Molecular Sciences, Italian Pharmacological Society, Cell Death Research Group - University of Alabama at Birmingham, USA.
In 2010, in collaboration with Dr. Nicola Antonucci, he founded a research group to study cellular and molecular changes in autism spectrum disorders. Author or co-author of 54 scientific peer-reviewed papers and 9 book chapters. His works received 723 citations so far. Presented 95 communications/abstracts to national and international conferences. He is serving as an editorial board member and reviewer of more than 40 international journals. His main research interests: gene expression and molecular regulation in autism spectrum disorders; use of stem cells as therapeutic tool in autism; role of macrophage activation in autism. Other research interests: stem cells therapy for the neuronal recovery; studying of neuronal apoptosis. Role of bcl-2 family, caspases, and cell cycle regulator genes.
Gene expression changes in autism disease. Protease activation in autism. Stem cell activation. Use of human mesenchymal stem cells as therapeutic tool in neurodegeneration. Studying of neuronal apoptosis. Role of bcl-2 family, caspases, and cell cycle regulator genes. Stem cells therapy for the neuronal recovery after central and peripheral nervous system injury. Apoptotic genes expression. Apoptosis and neuropathic pain. Role of reactive oxygen species in apoptosis.Molecular regulation of neural stem cell death. Apoptosis in neural precursor cells. Osteoclastic cell activation. Role of metabotropic glutamate receptors in the neuropathic pain pathway. Role of ozone in neuropathic pain treatment. Role of metabotropic glutamate receptors in the asthma. Protein expression at low temperature.